3α-Azido-5-cholestene
نویسندگان
چکیده
The crystal structure of the title compound, C(27)H(45)N(3), has been determined as part of our investigation into the hydro-phobic modification of amino-glycoside anti-biotics. The isopropyl group showed disorder for the tertiary carbon (equal occupancies), with high thermal motion for the peripheral atoms of the isopropyl and azide groups also apparent in the structure. The axial disposition of the azide group is consistent with the clean inversion of stereochemistry at C-3 under Mitsunobu conditions.
منابع مشابه
Practical Synthesis of 3 -Amino-5-cholestene and Related 3 -Halides Involving i-Steroid and Retro-i-Steroid Rearrangements
Derivatives of 3 -amino-5-cholestene (3 -cholesterylamine) are of substantial interest as cellular probes and have potential medicinal applications. However, existing syntheses of 3 -amino-5-cholestene are of limited preparative utility. We report here a practical method for the stereoselective preparation of 3 -amino-5-cholestene, 3 -chloro-5-cholestene, 3 -bromo-5-cholestene, and 3 -iodo-5-ch...
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